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The Vitamin D Radio

Monday, December 19th, 2022

The vitamin D receptor (VDR) is a health proteins that is stimulated by calciferol. It is involved in maintaining the mineral equilibrium in the body and contributing to growth and hair advancement. It also interacts with adipose muscle.

VDRs happen to be expressed in the parathyroid glands, intestines, epithelial cells, and many defense cell types. They are thought to regulate the intestinal consumption of calcium, and to mediate some of the associated with vitamin D about bone routine service. Fortunately they are thought to play an important role in metabolic rate.

VDR can be found in a variety of areas, including epithelial cells, macrophages, neutrophils, and skin keratinocytes. However , they may be most widely expressed in the kidneys and osseous matter.

The VDR is phosphorylated about serine residues by several protein kinases. These kinases include PKA and PKC. The effect of them kinases in VDR is definitely ligand based mostly. Specifically, the phosphorylation of Ser51 simply by PKC decreased VDR nuclear localization. Likewise, phosphorylation of Ser182 by PKA reduced RXR heterodimerization.

Research have shown that VDRs can be found in a subset of glial cells, particularly in oligodendrocytes in white matter. Although VDR immunoreactivity has been discovered in a number of glial cell lines, no information has been provided that the existence of VDR in glia is a cause for increased likelihood of tumorigenesis.

Additionally , VDR seems present in a subset of neurons. In fact , nuclear staining has been proven in our cortex and glial cell-lines.

A large 220-kDa protein can be found in human main glioblastoma cells. In contrast, a small recombinant VDR-like protein was produced.